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REACTIVE LESIONS AT THE CHORIO‐RETINAL JUNCTION: An Experimental Study
Author(s) -
NICOLAISSEN B.
Publication year - 1983
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1983.tb01435.x
Subject(s) - retinal pigment epithelium , retinal , choroid , horseradish peroxidase , pathology , retina , retinal degeneration , retinal detachment , inflammation , degeneration (medical) , anatomy , medicine , biology , chemistry , ophthalmology , immunology , biochemistry , enzyme , neuroscience
Addition of increased amounts of serum and a protein (peroxidase from horseradish) to the culture medium caused structural alterations in previously confluent cultures composed of cells from the human retinal pigment epithelium and choroid. The alterations consisted in the formation of bi‐ and multi‐layered strands, plaques and nodular structures and in the detachment of cells with formation of nude areas. These alterations resemble the frequently observed reactive alterations at the chorio‐retinal junction in eyes with inflammation, trauma, retinal detachment and certain degenerative disease processes as the senile disciform macula degeneration.