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EFFECTS OF PANCREATIC ISLET IMPLANTATION ON THE MORPHOLOGY OF RETINAL CAPILLARIES IN ALLOXAN DIABETIC MICE
Author(s) -
NAESER PETER,
ANDERSSON ARNE
Publication year - 1983
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1983.tb01392.x
Subject(s) - islet , diabetic retinopathy , diabetes mellitus , retinal , medicine , endocrinology , alloxan , retina , ophthalmology , biology , neuroscience
Intrasplenic implantation of syngeneic islets normalized the hyperglycaemia of alloxan‐diabetic mice irrespective of whether the implantation was performed 2 weeks or 4 months after the induction of diabetes. Islet implantation soon after the onset of diabetes prevented the development of retinal capillary disease as evidenced by a normal ratio between endothelial cells and pericytes. The increase of the cell count ratio (endothelial cells/pericytes) induced by long‐term diabetes could not, however, be restored by islet implantation. The present results further underline the importance of optimal treatment for prevention of diabetic retinopathy.