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THE EFFECT OF PROSPECTIVE HLA‐A AND ‐B MATCHING ON CORNEAL GRAFT SURVIVAL
Author(s) -
VÖLKERDIEBEN H. J.,
ALPHEN C. C. KOKVAN,
LANSBERGEN Q.,
PERSIJN G. G.
Publication year - 1982
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1982.tb08374.x
Subject(s) - human leukocyte antigen , medicine , matching (statistics) , corneal transplantation , prospective cohort study , corneal graft , surgery , hla a , cornea , ophthalmology , immunology , antigen , pathology
The effect of prospective HLA‐A and ‐B matching on corneal graft survival was studied in 159 Dutch recipients. The follow‐up period ranges from 3 months to 4 1/2 years. In the same period 380 grafts were performed at random. The influence of HLA‐A and ‐B matching on graft survival in all vascularized cases (n = 137) was significant ( P = 0.046). If the non‐immuno‐logical failures are excluded the effect of HLA‐A and ‐B matchings becomes more pronounced ( P = 0.027). The influence of HLA‐A and ‐B matching on the graft survival of only the first grafts in vascularized corneas was more significant ( p = 0.028). Finally a significant influence of HLA‐A and ‐B matching was also found in repeated grafts in vascularized corneas ( P = 0.037).