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ACYCLOVIR AND IDOXIURIDINE TREATMENT OF HERPES SIMPLEX KERATITIS — A DOUBLE BLIND CLINICAL STUDY
Author(s) -
KLAUBER ANNE,
OTTOVAY EVA
Publication year - 1982
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1982.tb06748.x
Subject(s) - double blind , keratitis , medicine , dermatology , adverse effect , aciclovir , clinical trial , cure rate , surgery , virology , herpesviridae , pathology , viral disease , virus , alternative medicine , placebo
38 patients with herpes simplex keratitis were treated in double blind clinical trial. 18 patients (10 with pure epithelial and 8 with accompanying stromal affection) were treated with 3% acyclovir (ACV) eye ointment, and 20 patients (10 with pure epithelial and 10 with accompanying stromal affection) were treated with 0.5% idoxiuridine (IDU). The cure rate was 94% in the ACV group compared to 70% in the IDU group. This was significantly higher in the ACV group. Only minor adverse reactions were recorded.