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HLA AND OPHTHALMIC DISEASE ASSOCIATIONS: A Critical Review and Improved Method for Statistical Analysis
Author(s) -
MARGO CURTIS E.,
TROBE JONATHAN D.,
SHUSTER JONATHAN J.
Publication year - 1982
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1982.tb00598.x
Subject(s) - human leukocyte antigen , statistical analysis , statistical significance , histocompatibility , disease , medicine , computer science , statistics , immunology , mathematics , pathology , antigen
A critical review of published ophthalmic histocompatibility antigen association studies found numerous conflicting or ambiguous reports. Methodologic errors that could account for these discrepancies were categorized into 3 groups (1) arbitrary application of statistical methods to determine significance, (2) poor sampling design, and (3) variable disease definition. Multivariate analysis, not previously applied in this area provides a more powerful tool for assessing statistical significance. A computer program using this methodology for large studies is now available.