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AQUEOUS HUMOUR AND PLASMA AMINO ACIDS IN TAPETO‐RETINAL DEGENERATIONS
Author(s) -
EHLERS NIELS
Publication year - 1981
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1981.tb08345.x
Subject(s) - aqueous humour , taurine , glutamine , retinal , retinitis pigmentosa , cystine , glycine , chemistry , amino acid , glutamic acid , aqueous solution , proline , aqueous humor , biochemistry , medicine , ophthalmology , organic chemistry , cysteine , enzyme
The concentration of 18 amino acids and related compounds has been determined in plasma and aqueous humour in 17 patients with tapeto‐retinal degenerations, among them 10 patients with retinitis pigmentosa. When compared with a previously obtained reference series of 40 patients abnormal aqueous concentrations (C aq ) were found for taurine, glutamine, glutamic acid, proline, glycine, α‐ANBA and cystine. As regards the plasma concentrations (C pl ) only glutamic acid and α‐ANBA showed abnormal values. Several of the substances showing abnormal concentrations are possible neurotransmittors or inhibitors. The results suggest that aqueous humour analysis will be a useful way of studying retinal degenerations.