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A DIURNAL STUDY OF THE OCULAR HYPOTENSIVE EFFECT OF METOPROLOL MOUNTED ON OPHTHALMIC RODS COMPARED TO TIMOLOL EYE DROPS IN GLAUCOMA PATIENTS
Author(s) -
NIELSEN NIELS VESTI
Publication year - 1981
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1981.tb08334.x
Subject(s) - metoprolol , intraocular pressure , medicine , timolol , glaucoma , blood pressure , heart rate , eye drop , ophthalmology , anesthesia , ocular hypertension
In a cross over study the diurnal effects of metoprolol 0.22 mg mounted on ophthalmic rods and timolol eye drops (0.5%) was compared with respect to intraocular pressure, heart rate and blood pressure. Eleven glaucoma patients, 56–80 years old, were treated. No significant difference in ocular hypotensive action was disclosed between these two agents. The median or mean percentage hypotensive effect of both agents did not exceed 26%. The maximum pressure reduction occurred during the first 4 h after treatment. Both agents appeared to influence the heart rate and mean arterial pressure 1 —4 h after ocular application. The administration of 0.22 mg metoprolol on ophthalmic rods produces seemingly a similar effect on intraocular pressure, blood pressure and heart rate as one eye drop of 3 % metoprolol.