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EARLY EFFECTS OF SODIUM IODATE ON THE DIRECTLY RECORDED STANDING POTENTIAL OF THE EYE AND ON THE c‐WAVE OF THE DC REGISTERED ELECTRORETINOGRAM IN ALBINO RABBITS
Author(s) -
TEXTORIUS OLA,
WELINDER EVA
Publication year - 1981
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1981.tb03001.x
Subject(s) - cornea , erg , chemistry , sodium , iodate , endocrinology , medicine , ophthalmology , iodine , biochemistry , retinal , organic chemistry
The early effects of intravenously administered sodium iodate (NaIO 3 ) on the directly recorded standing potential (SP) of the eye and on the c ‐ and b ‐waves of the DC registered ERG were studied in 8 anaesthetized albino rabbits. In 5 of 6 animals obtaining 40 mg NaIO 3 /kg bwt. the SP decreased immediately following the injection, and had attained a level 3.5–4 mV below the original one after 1 h. The c ‐wave declined rapidly and 6 min after the injection it was replaced by a large cornea‐negative potential. The b ‐wave was relatively unchanged except in one animal. In 2 rabbits treated with 30 mg NaIO 3 /kg bwt. and in the 6th animal obtaining 40 mg NaIO 3 /kg bwt. an SP increase instead of a decrease was seen, and the c ‐wave was more slowly (about 22 min after the injection) replaced by the cornea‐negative potential. The b ‐wave was somewhat increased. These results demonstrate the dose‐related and interindividual variability in the SP reaction to NaIO 3 and are in good agreement with the well‐known ultrastructural pigment epithelial injury and c ‐wave changes produced by this substance.