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INFLUENCE OF TRANEXAMIC ACID AND ACETYLSALICYLIC ACID ON THE THICKNESS OF THE NORMAL CORNEA
Author(s) -
OLSEN THOMAS,
EHLERS NIELS,
BRAMSEN THORKILD
Publication year - 1980
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1980.tb06690.x
Subject(s) - tranexamic acid , cornea , medicine , ophthalmology , surgery , blood loss
In a masked cross‐over study ten normal subjects were treated with tranexamic acid and acetylsalicylic acid one g three times daily for seven days. The central corneal thickness was found to increase in response to acetylsalicylic acid and to decrease in response to tranexamic acid. This finding provides evidence for the involvement of the fibrinolytic system in the regulation of the normal corneal thickness. The endothelial morphology, as seen with the specular microscope, was unchanged during treatment with either drug.