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HISTOPATHOLOGY OF THE LENS CAPSULE IN FIBRILLOPATHIA EPITHELIOCAPSULARIS (FEC) OR SO‐CALLED SENILE EXFOLIATION OR PSEUDOEXFOLIATION
Author(s) -
SELAND JOHAN H.
Publication year - 1979
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1979.tb01832.x
Subject(s) - pseudoexfoliation , capsule , ultrastructure , lens (geology) , anatomy , exfoliation joint , ophthalmology , materials science , optics , biology , medicine , glaucoma , botany , physics , graphene , nanotechnology
Twenty lenses from cataractous eyes have been subjected to enzymatic breakdown by collagenase and α‐chymotrypsin in order to remove part of the lens capsule and the zonular apparatus. Twelve of the lenses had clinical fibrillopathia epitheliocapsularis (FEC syndrome). In addition four FEC lenses and four ordinary cataractous lenses served as controls. A characteristic fibrillar substance was found in the FEC lenses located to circular epithelium‐near areas varying in size from 10 μm to 150 μm. The circular areas were found in zona germinativa in front of the bow region and corresponded to the discoid plaques of the deep layer. The ultrastructure of the finely fibrillar material of the deep layer were indistinguishable from that of the surface material of the peripheral band and the central disc. A connection between the discoid plaques of deep layer and the peripheral granular band were demonstrated in the form of radial “cobble‐stone” sectors seen in partially digested FEC capsules. An increased amount of age dependent spindleshaped formed bodies were also found in FEC lenses. The evidence presented points towards a lenticular origin of the Busaccabushes in the peripheral ganular band of the lens capsule.