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EOG IN A LARGE FAMILY WITH HEREDITARY MACULAR DEGENERATION
Author(s) -
THORBURN W.,
NORDSTRÖM S.
Publication year - 1978
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1978.tb05699.x
Subject(s) - offspring , macular degeneration , degeneration (medical) , medicine , family history , ophthalmology , mean value , physiology , genetics , biology , pregnancy , mathematics , statistics
A total of 128 descendants from one large family with a history of hereditary macular degeneration (HMD) were examined with EOG. Of these, 42 were affected patients, 48 were healthy offsprings to affected parents, and 38 were normal controls. Affected subjects had a light peak/dark trough ratio smaller than 1.40. In the group of offspring of affected parents the Lp/Dt ratios showed a bimodal distribution dividing the group into two parts, one with values less than 1.40 and another with values larger than 1.70. Thus carriers of the HMD gene can apparently be identified by use of EOG. The affected subjects and the carriers had a lower base value of the standing potential than the controls.