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BIOLOGICAL VARIATION OF IMMUNOGLOBULIN CONCENTRATIONS IN NORMAL HUMAN TEARS RELATED TO AGE AND SEX
Author(s) -
SEN D. K.,
SARIN G. S.,
MATHUR G. P.,
SAHA KUNAL
Publication year - 1978
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1978.tb05697.x
Subject(s) - radial immunodiffusion , immunoglobulin d , tears , immunodiffusion , antibody , immunoglobulin a , age groups , medicine , immunology , biology , immunoglobulin g , demography , b cell , sociology
Single radial immunodiffusion method was used to measure the concentration of IgG, IgA, IgM and IgD in tears of 220 healthy individuals aged from 2 to 86 years. Relation of the values to age and sex has been evaluated statistically by regression analysis method. Mean IgA level was 30.7 mg/100 ml. IgG could be detected in 200 samples and the level was less than 1 mg/100 ml. IgM was detected in only 7 samples and the value was less than 1 mg/100 ml. IgD could not be detected in any of the sample. The IgA level in males and that in females differs significantly, the females having a higher mean value. The IgA level appears to increase in both sexes with age. No relationship with age and sex could be established in other types of immunoglobulins.