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CORTICOSTEROID RESPONSE IN DOMINANT CONGENITAL GLAUCOMA
Author(s) -
JERNDAL TORD,
MUNKBY MARGARETA
Publication year - 1978
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1978.tb05690.x
Subject(s) - glaucoma , corticosteroid , medicine , ophthalmology , optometry
The parents of six children with goniodysgenesis and hereditary infantile congenital glaucoma were tested with corticosteroid eye‐drops. Their response on provocation demonstrated a clear trend: In five families one parent of each couple responded with a tensional rise of 9 mmHg or more, whereas the other parent responded with a rise of 9 mmHg or less. Of the six parents with the greater response, five had glaucoma in their ancestry and displayed a distinct goniodysgenesis. The findings support the previously presented view that hereditary infantile congenital glaucoma is caused by a dominant goniodysgenesis with varying expressivity. The high corticosteroid response in the families of our study appears to be correlated to this goniodysgenesis. The inherited corticosteroid response is obviously not a specific genetic trait confined to families with simple glaucoma.