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STUDIES ON ACUTE AND LATE STAGES OF EXPERIMENTAL CENTRAL RETINAL ARTERY OCCLUSION IN THE CYNOMOLGUS MONKEY
Author(s) -
TEXTORIUS OLA,
NILSSON SVEN ERIK G.,
SKOOG KLASOLAV
Publication year - 1978
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1978.tb01377.x
Subject(s) - retina , retinal , erg , occlusion , potassium , ophthalmology , medicine , anatomy , chemistry , biology , neuroscience , organic chemistry
The main positive component of the c ‐wave of the ERG is generated by the pigment epithelium — receptor complex, which is supplied from the choroidal circulation. Occlusion of the central retinal artery (OCRA) causes serious morphological damage only to the inner retina. An effect on the c ‐wave is therefore not primarily to be expected. In this study on five Cynomolgus monkeys with unilateral, laser‐induced OCRA the c‐wave was decreased, slightly in the early stage and markedly in the late stage. A hypothetical explanation of the reduced c ‐wave amplitude, involving changes in potassium ion concentration, is discussed. The conflicting results in other reports may be explained by uncontrolled influence of slow c ‐wave amplitude oscillations, by differences between acute and late stages, and by possible surgical damage to the choroidal circulation in some cases.