Premium
EFFECT OF VEHICLE ON PILOCARPINE‐INDUCED MIOSIS
Author(s) -
SAARI MATTI,
KOSKELA PENTTI,
MASAR SVENERIK
Publication year - 1978
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1978.tb01362.x
Subject(s) - pilocarpine , miosis , ophthalmology , medicine , optometry , anesthesia , epilepsy , psychiatry
To determine the effect of 1.4% polyvinyl alcohol (PVA) and castor oil vehicles on the pilocarpine‐induced miosis, we studied the miotic effect of 2% pilocarpine‐PVA and oily drops on 4 young and 10 elderly people and the miotic effect of 4 % pilocarpine‐PVA and oily drops on 13 elderly people. The miosis developed fast within 15 min, and maximum miosis was rached within 1 h. Oily drops of pilocarpine induced stronger maximum miosis than corresponding PVA‐drops. The pupil remained contracted to less than 50 % of its starting diameter after pilocarpine‐PVA drops for 3–4 h and after oily drops for 9 h and returned to its starting diameter after pilocarpine‐PVA drops 9–10 h and after oily drops 20–24 h following administration. The difference in the effect between pilocarpine‐PVA and oily drops was independent of the subjects' age.