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A DOUBLE‐BLIND CLINICAL TRIAL OF A GUANETHIDINE/ADRENALINE COMBINATION, COMPARED WITH THE TWO SEPARATE COMPONENTS, IN GLAUCOMA
Author(s) -
ELTZ H.,
AESCHLIMANN J.,
GLOOR B.
Publication year - 1978
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1978.tb01345.x
Subject(s) - guanethidine , glaucoma , intraocular pressure , medicine , double blind , ophthalmology , anesthesia , alternative medicine , pathology , stimulation , placebo
In a double‐blind cross‐over study, the intraocular pressure‐lowering action and side effects of a 5% guanethidine/1% adrenaline combination were studied and compared with those of the two components alone. The subjects were 63 glaucoma patients divided into three random groups given the three preparations in a different order. The pressure‐lowering effect of the combination is significantly better ( P < 1%) than that of either component alone but the side effects were more severe.