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THE EFFECT OF EXPERIMENTAL UVEITIS ON THE UPTAKE OF PROSTAGLANDIN E 1 IN THE RABBIT IRIS‐CILIARY BODY
Author(s) -
BENGTSSON ELISABETH,
EHINGER BERNDT
Publication year - 1977
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1977.tb05667.x
Subject(s) - uveitis , ciliary body , prostaglandin , iris (biosensor) , aqueous humor , prostaglandin e2 , endocrinology , chemistry , hormone , prostaglandin e , melanocyte stimulating hormone , sterility , medicine , prostaglandin e1 , biology , ophthalmology , computer security , computer science , biometrics , genetics
Disruption of the blood‐aqueous barrier in rabbits was elicited by infrared irradiation of the iris or by α‐melanocyte stimulating hormone (α‐MSH) given subcutaneously. One group of animals was pretreated with topical imidazole before the injection of α‐MSH. The aqueous flare response was followed and the rabbits were killed at the expected height of the uveitis. The uptake of 3 H‐prostaglandin E 1 in the iris with the ciliary body was then determined and found to be significantly decreased in the rabbits in which α‐MSH had caused a severe damage of the blood‐aqueous barrier. When α‐MSH caused a more moderate aqueous flare response the prostaglandin uptake was on the contrary significantly increased. Pretreatment of the animals with topical imidazole enhanced parallelly the prostaglandin uptake and the aqueous flare response to α‐MSH. Topical imidazole per se was found to increase the accumulation of prostaglandin. The prostaglandin uptake values were, however, unchanged in eyes in which infrared irradiation of the iris induced a moderate flare response.