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THE CYCLOPENTOLATE PROVOCATIVE TEST IN SUSPECTED OR UNTREATED OPEN‐ANGLE GLAUCOMA
Author(s) -
VALLE OLAVI
Publication year - 1976
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1976.tb01800.x
Subject(s) - ophthalmology , intraocular pressure , cyclopentolate , medicine , glaucoma , mydriasis , aqueous humor , open angle glaucoma , aqueous humour
The mydriasis provocative test with 1% cyclopentolate (CPT) was performed on 431 eyes with suspected or untreated open‐angle glaucoma. Tonography was performed both before and during CPT to study the changes in aqueous dynamics during the test. Statistical analysis of the results yielded the following mean trends and correlations at a highly significant level ( P < 0.001) in the alterations: Intraocular pressure (IOP) rose (ΔP ± SD) (+1.4 ± 2.9 mmHg) and aqueous outflow facility decreased (ΔC) (‐10%) during CPT. The distribution of ΔP and ΔC did not follow the normal Gaussian distribution. The change in ΔP deviated from the Gaussian distribution in 5–10% of the eyes. The deviating values concur with those of the responder eyes in which IOP rose ≧8 mmHg during CPT. ΔP was linearly dependent on the initial IOP level P o and the absolute change was always almost constant, ˜ +1.4 mmHg. Both the total series and the responder eyes displayed the same trend for the change in aqueous outflow facility in relation to the initial C value (C 0 ): low C 0 values changed less on average and high C 0 values changed more and diminished. It is not known why the ΔC change was different depending on the C 0 value. The change in IOP correlated statistically highly significantly with the initial C value (C 0 ). The lower the C 0 value, the higher was the mean IOP elevation during CPT. In contrast, the change in aqueous outflow (ΔC) did not correlate (N. S.) with the initial IOP level (P 0 ) before CPT.