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CONCENTRATIONS OF SOME RIBONUCLEOTIDES, L‐LACTATE, AND PYRUVATE IN HUMAN SENILE CATARACTOUS LENSES WITH SPECIAL REFERENCE TO ANTERIOR CAPSULAR/SUBCAPSULAR OPACITY
Author(s) -
LAURSEN A. BRUUN
Publication year - 1976
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1976.tb01787.x
Subject(s) - ribonucleoside , lens (geology) , chemistry , senile cataract , endocrinology , biochemistry , biology , medicine , ophthalmology , rna , paleontology , gene
The concentrations of some ribonucleoside tri‐ and diphosphates, adeno‐sine‐5′‐monophosphate, L‐lactate and pyruvate were determined in human senile cataractous lenses removed during cataract operations. Pyruvate concentrations were found to be negligible (median = 56 μmol/kg lens wet weight) in 15 human senile cataractous lenses. On the basis of correlations between the biomicroscopic appearances of the senile cataractous lenses (N = 80) and the concentrations and ratios of the metabolites in question, the following classification was found to be justified:1 Immature cataractous lenses without anterior capsular/subcapsular opacity: high levels of ribonucleoside triphosphates (RTP), high sums of RTP, ribonucleoside diphosphates (RDP), and adenosine‐5′‐monophosphate (AMP) as well as high levels of L‐lactate and high ratios of L‐lactate in the lens/L‐lactate i n the aqueous. 2 Immature cataractous lenses with anterior capsular/subcapsular opacity: intermediate levels of RTP, intermediate values for the sums of RTP, RDP, and AMP, high L‐lactate levels, and intermediate values of the ratios of L‐lactate in the lens/L‐lactate in the aqueous. 3 Totally opaque lenses, which all had extensive anterior capsular/subcapsular opacity: low values for the concentrations of lens RTP, for the sums of RTP, RDP and AMP, and for lens L‐lactate. Low ratios of L‐lactate in the 1ens/L‐lactate in the aqueous.