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EFFECT OF ORALLY ADMINISTERED HYDROCORTISONE ON THE OCULAR TENSION IN PRIMARY OPEN‐ANGLE GLAUCOMA SUBJECTS
Author(s) -
KIMURA RYOZO,
MAEKAWA NOBUO
Publication year - 1976
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1976.tb01274.x
Subject(s) - open angle glaucoma , hydrocortisone , diurnal temperature variation , ophthalmology , medicine , normal tension glaucoma , glaucoma , physics , meteorology
We studied the possible influence on the pattern of diurnal ocular tension curve by peroral hydrocortisone in 16 eyes of 16 subjects with primary open‐angle glaucoma. The baseline diurnal curve was determined by Schiøtz tonometry six times daily starting at 10 a. m. and repeated every four hours. The baseline curve showed a significant rise in the daytime with a fall during the night. On another day, 20 mg hydrocortisone was given perorally at 5 p. m., for a repeat 24‐h measurement period. A significant rise in ocular tension over the baseline resulted in the following night‐time tonometric readings, i. e. at 10 p. m. ( P < 0.01) and 2 a. m. ( P <0.001). The results seem to strongly indicate that plasma corticosteroid levels dictate the pattern of diurnal variation of ocular tension.