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MELANOTROPIC DRUGS AND RETINAL FUNCTIONS
Author(s) -
CALISSENDORFF BERIT
Publication year - 1976
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1976.tb00424.x
Subject(s) - chlorpromazine , promethazine , phenothiazine , erg , electroretinography , retinal , medicine , concomitant , retina , pharmacology , chemistry , ophthalmology , optics , physics
The acute effects of chlorpromazine, promethazine and rifampicin on the a ‐, b ‐ and c ‐waves of the conventional electroretinogram (ERG) were studied in sheep. Iv administration of chlorpromazine and promethazine resulted in a b ‐wave amplitude decrease and an initial c ‐wave amplitude decrease, followed by cyclic amplitude changes resembling damped oscillations. Iv injections of rifampicin, however, resulted in cyclic changes of the c ‐wave amplitude without initial concomitant b ‐wave changes. The results of the present study indicate that rifampicin has a selective influence on the pigment epithelial cells, while chlorpromazine and promethazine seem to have more generalized retinal effects on both the neuro‐retina and the pigment epithelial cells.