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MELANOTROPIC DRUGS AND RETINAL FUNCTIONS
Author(s) -
CALISSENDORFF BERIT
Publication year - 1976
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1976.tb00423.x
Subject(s) - retinal , optometry , ophthalmology , medicine
The present work is the first in a series of investigations on the effects of melanotropic drugs on retinal functions. The changes in the conventional ERG of the dark‐adapted, intact sheep eye were studied after iv administrations of quinine and chloroquine. Both drugs influenced the ERG in principally the same way. Small doses changed only the c ‐wave amplitude which began to oscillate after a delay of about 1 hour. Larger doses had an immediate effect on both the b ‐ and c ‐waves. The b ‐wave amplitude dropped and the c ‐wave showed an initial peak followed by oscillatory changes about 1 h later. These late changes were similar to those observed after administration of small doses of the drugs. The present results indicate that small doses of quinine and chloroquine have a delayed effect on the pigment epithelial cells, while larger doses exert a more immediate and general retinotoxic effect.