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HISTOCOMPATIBILITY MATCHING IN POOR‐PROGNOSIS PENETRATING KERATOPLASTY
Author(s) -
BENNETT THOMAS O.,
PEYMAN GHOLAM A.,
TISSOT ROBERT,
COHEN CARL
Publication year - 1975
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1975.tb01172.x
Subject(s) - locus (genetics) , histocompatibility , significant difference , ophthalmology , medicine , biology , human leukocyte antigen , genetics , immunology , antigen , gene
Rabbits were haplotyped for the major rabbit leukocyte‐locus A (RL‐A locus), which is analogous to the human leukocyte‐locus A (HL‐A locus). The rabbits were divided into five groups, and the groups were arranged to provide a controlled experimental setting. Standardized alkali burns were induced in selected groups to produce heavy vascularization of the corneal bed. Groups with completely histocompatible corneal donors for the RL‐A locus had a 9 out of 10 success rate when keratoplasty was performed on a vascularized bed. Another group of rabbits mismatched at the RL‐A locus with histoincompatible corneal donors were prepared in the same manner and had a success rate of 1 out of 9. A probable significant difference ( P < 0.005) using Fischer's exact test was found between the two groups.