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INTRAVITREAL INJECTION OF VANCOMYCIN IN EXPERIMENTAL STAPHYLOCOCCAL ENDOPHTHALMITIS
Author(s) -
HOMER PAUL,
PEYMAN GHOLAM A.,
KOZIOL JEFF,
SANDERS DONALD
Publication year - 1975
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1975.tb01162.x
Subject(s) - endophthalmitis , vancomycin , medicine , staphylococcus aureus , therapeutic effect , intravitreal administration , aqueous humor , antibiotics , anesthesia , ophthalmology , surgery , microbiology and biotechnology , bacteria , biology , genetics , retinal
Toxicity, clearance, and therapeutic effectiveness of intravitreal vancomycin hydrochloride injection in experimentally induced staphylococcal endophthalmitis were evaluated. Vancomycin was found to be nontoxic in a single, 1 mg/0.1 ml intravitreal dose. Therapeutic levels of vancomycin were present in the vitreous for over 72 hours and in the aqueous during a period from 6 to 48 hours after injection. Injection of a methicillin‐resistant Staphylococcus aureus produced a panophthalmitis in our systemically treated controls, whereas in the rabbits treated by intraocular injection, the course of the infection was significantly altered.