Premium
GLUCOSE, PYRUVATE AND CITRATE CONCENTRATIONS IN THE AQUEOUS HUMOUR OF HUMAN CATARACTOUS EYES
Author(s) -
LAURSEN A. BRUUN,
LORENTZEN S. E.
Publication year - 1974
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1974.tb01759.x
Subject(s) - aqueous humour , senile cataract , cataracts , aqueous humor , medicine , endocrinology , metabolite , chemistry , ophthalmology
Results are reported of determinations of glucose concentrations in aqueous humour and plasma, of pyruvate concentrations in aqueous humour, and of citrate concentrations in aqueous humour and plasma from 22 non‐fasting and 17 fasting patients with senile cataracts, five fasting diabetics with senile cataracts, and four patients with cataract and other ocular diseases. Higher pyruvate concentrations were found in the non‐fasting group with senile cataract than in the fasting senile cataract group ( P < 0.01). The group of diabetics likewise presented higher pyruvate concentrations than the group of fasting senile‐cataractous patients ( P < 0.05). The Spearman coefficient of rank correlation showed a positive correlation between cataract density and citrate concentrations in the aggregate series ( P < 0.05). Senile cortical cataracts and senile nuclear plus cortical cataracts differed in that the citrate aqueous/citrate plasma ratio calculated for the whole series collectively was the lowest in the latter group ( P < 0.05). Further investigations into the metabolite concentrations at different stages of cataract are, however, required, as an error of the first kind because of multiple significance tests cannot be left out of account in the present material.