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EFFECTS OF ARTIFICIAL INTRAOCULAR PRESSURE ELEVATION ON THE OUTFLOW FACILITY AND THE ULTRASTRUCTURE OF THE CHAMBER ANGLE IN THE VERVET MONKEY (Cercopithecus ethiops)
Author(s) -
SVEDBERGH BJÖRN
Publication year - 1974
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1974.tb01120.x
Subject(s) - trabecular meshwork , intraocular pressure , vervet monkey , schlemm's canal , outflow , ophthalmology , ultrastructure , anatomy , aqueous humor , endothelium , cytoplasm , biology , chemistry , medicine , microbiology and biotechnology , physics , endocrinology , zoology , meteorology
Both eyes of anaesthetized vervet monkeys were perfused with mock aqueous humor for 3–7 hours. By adjusting the height of a reservoir connected to each eye the intraocular pressure in one eye was maintained at 33–48 mmHg and in the other eye it was a few mmHg above the spontaneous level. The facility of outflow in the high pressure eye increased by an average of 350% (160–630%), whereas the increase in the control eye was less than 40%. Morphologically the control eyes appeared normal, whereas pronounced changes were observed in the high pressure eyes. The endothelial cells in the trabecular meshwork were swollen and demonstrated loss of cytoplasm. Cell debris and “ blebs ” were observed in the intertrabecular spaces. The endothelial meshwork and the endothelium of the inner wall of Schlemm's canal were partly disrupted. The outflow facility was normalized within 1 day but marked morphological changes were still present.