Premium
INCREASED VON WILLEBRAND‐ANTIHAEMOPHILIC FACTOR A IN DIABETIC RETINOPATHY
Author(s) -
PANDOLFI MAURIZIO,
ALMÉR LARSOLOF,
HOLMBERG LARS
Publication year - 1974
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1974.tb01119.x
Subject(s) - diabetic retinopathy , von willebrand factor , medicine , platelet adhesion , platelet , retinopathy , platelet adhesiveness , endocrinology , ophthalmology , platelet aggregation , diabetes mellitus
The von Willebrand factor‐Factor VIII (vW‐AHF) related protein and the AHF (antihaemophilic factor A) activity have been measured in the blood of 63 diabetic patients with and without diabetic retinopathy. Compared to normals, diabetic patients showed a clear increase in both vW‐AHF related protein and AHF activity. Patients with retinopathy had a level of vW‐AHF related protein significantly higher than patients without retinopathy. Since the von Willebrand factor is involved in the mechanism of platelet adhesion and aggregation these findings may contribute to an explanation of the increased platelet stickiness known to occur in diabetics and especially in those with retinal changes.