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AN ANGIOGRAPHIC AND HISTOLOGIC STUDY OF THE VASCULATURE OF CHOROIDAL MALIGNANT MELANOMA
Author(s) -
YANKO L.
Publication year - 1973
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1973.tb08241.x
Subject(s) - choroid , pathology , melanoma , medicine , fluorescein angiography , hyaline , angiography , pathological , retina , retinal , radiology , biology , ophthalmology , cancer research , neuroscience
Ten cases of malignant melanoma of the choroid, examined by fluorescein angiography and routine histologic methods, are reported, and correlation between the angiographic and microscopic findings is attempted. It is suggested that the fluorescent angiographic appearances in malignant melanoma are better understood in terms of the basic vascular patterns of the tumor as revealed by histology. In assessing the earliest patterns revealed by fluorescein angiography, the initial presence of a loose vascular network and the later appearance of fluorescent dots are readily understood if the histologic arrangement of the tumor vessels is borne in mind. The presence of wall‐less tumor blood channels and secondary changes such as hyaline degeneration of the vessel wall and tumoral cells are probably responsible for the late angiographic patterns and the residual fluorescence found in these tumors. The pigment content of the tumor, hemorrhages within the tumor, the presence of subretinal fluid, and vascular damage of the overlying retina are further variables which must be considered when interpreting the pattern of fluorescein angiography in this pathological condition.