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SYSTEMIC STEROIDS AND OCULAR FLUID DYNAMICS. I
Author(s) -
GODEL V.,
FEILEROFRY V.,
STEIN R.
Publication year - 1972
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1972.tb06606.x
Subject(s) - dose , medicine , steroid , applanation tonometry , anesthesia , intraocular pressure , surgery , blood pressure , hormone , arterial stiffness
Sixty patients treated for various systemic diseases with long‐term steroids of varying dosages and durations showed a significantly higher mean applanation pressure than both a normal control group and literature populations. There was no significant difference between these groups for tonographic C values before drinking water, but lower values for C and higher values of the log of the Po/C ratio were found in the steroid group after water drinking. Cumulative per cent‐frequency plots for applanation pressures of the steroid patients revealed an obvious deviation to the right from a straight line in the upper end of the curve starting at the point of 60%, representing patients with pressures of 20 mmHg or higher. Presence of a higher mean applanation pressure and absence of an adequately reduced outflow facility in the systemic steroid group are interpreted as evidence of an increased formation of aqueous humor in individuals treated with steroids by this route. Analysis of the influence of dosage and duration of treatment disclosed that differences in the mean applanation pressure between these subgroups were not due either to duration or dosage of treatment but to the presence or absence of individuals within the group responding to steroids with an increase of pressure. The proof of this fact will be presented in the second part.