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RELEASE OF FIBRINOLYTIC ENZYMES FROM HUMAN CORNEA
Author(s) -
PANDOLFI M.,
ÅSTEDT B.,
DYSTERAAS K.
Publication year - 1972
Publication title -
acta ophthalmologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.534
H-Index - 87
eISSN - 1755-3768
pISSN - 1755-375X
DOI - 10.1111/j.1755-3768.1972.tb03778.x
Subject(s) - cornea , fibrin , plasmin , fibrinolysis , chemistry , tranexamic acid , inflammation , biochemistry , pharmacology , enzyme , immunology , medicine , surgery , ophthalmology , blood loss
The release of fibrinolytic agents from human cornea was studied by culturing foetal corneal explants in the presence of a standard fibrin clot and measuring the fibrin degradation products formed in the culture medium. Cultures of cornea were found to invariably release a significant amount of fibrinolytic agents, probably fibrinolytic activators, since Tranexamic acid, an inhibitor of plasminogen activation into plasmin, completely blocked the dissolution of the clot in the culture system. The function of these fibrinolytic activators is presumably to keep the cornea free from fibrin deposits which may occur after injury or inflammation.