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Mutational analysis of cutaneous squamous cell carcinomas and verrucal keratosis in patients taking BRAF inhibitors
Author(s) -
Anforth Rachael,
Tembe Varsha,
Blumetti Tatiana,
FernandezPeñas Pablo
Publication year - 2012
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/j.1755-148x.2012.01031.x
Subject(s) - actinic keratosis , keratosis , medicine , v600e , cancer research , dermatology , basal cell , mutation , pathology , biology , gene , biochemistry
Summary B‐RAF inhibitors (BRAFi) have been shown to improve rates of overall and progression‐free survival in patients with stage IV metastatic melanoma positive for the BRAF V600E mutation. However, the main drawback is the development of verrucal keratosis (hyperkeratotic papules with verruca‐like characteristics with benign histological findings) and cutaneous squamous cell carcinomas (cuSCC). We have found upstream mutations in RAS as well as PIK3CA in both verrucal keratosis and cuSCC. This suggests that verrucal keratosis is an early clinical presentation of cuSCC in patients on BRAFi.