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Breast cancer suppressor candidate‐1 (BCSC‐1) is a melanoma tumor suppressor that down regulates MITF
Author(s) -
Anghel Silvia I.,
CorreaRochal Rafael,
Budinska Eva,
Boliganl Kayluz F.,
Abraham Shahnaz,
Colombetti Sara,
Fontao Lionel,
Mariotti Agnese,
Rimoldi Donata,
Ghanem Ghanem E.,
Fisher David E.,
Lévy Frederic,
Delorenzi Mauro,
Piguet Vincent
Publication year - 2012
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/j.1755-148x.2012.01018.x
Subject(s) - microphthalmia associated transcription factor , melanoma , cancer research , suppressor , ectopic expression , biology , cancer , tumor suppressor gene , cell growth , regulator , transcription factor , carcinogenesis , cell culture , genetics , gene
Summary Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate‐1 (BCSC‐1) as a novel tumor suppressor in melanoma. BCSC‐1 expression is decreased in human MM, and its ectopic expression in MM–derived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC‐1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC‐1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.