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2,4,6‐Octatrienoic acid is a novel promoter of melanogenesis and antioxidant defence in normal human melanocytes via PPAR‐γ activation
Author(s) -
Flori Enrica,
Mastrofrancesco Arianna,
Kovacs Daniela,
Ramot Yuval,
Briganti Stefania,
Bellei Barbara,
Paus Ralf,
Picardo Mauro
Publication year - 2011
Publication title -
pigment cell and melanoma research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.618
H-Index - 105
eISSN - 1755-148X
pISSN - 1755-1471
DOI - 10.1111/j.1755-148x.2011.00887.x
Subject(s) - human skin , photoprotection , antioxidant , tyrosinase , melanocyte , melanin , microphthalmia associated transcription factor , microbiology and biotechnology , transcription factor , catalase , epidermis (zoology) , chemistry , biology , biochemistry , cancer research , enzyme , gene , genetics , anatomy , melanoma , photosynthesis
Summary Given the importance of the tanning response in protecting human skin from the harmful effects of UV radiation, one important research priority is to identify novel molecules that are capable of promoting pigmentation and/or antioxidant defence. Parrodienes share some structural features with carotenoids and retinoids, stimulate cell antioxidant defence and counteract senescence‐like phenotype in fibroblasts. We selected the parrodiene‐derivative 2,4,6‐octatrienoic acid (Octa) to study its impact on key parameters of melanogenesis and antioxidant defence in organ‐cultured human skin and in normal human melanocytes. Octa promoted melanogenesis by up‐regulating tyrosinase and microphthalmia‐associated transcription factor expression. This correlated with an increase of melanin content in both human epidermis in situ and cultured human epidermal melanocytes. Moreover, Octa increased the biological antioxidant potential content and the expression and activity of catalase. Activation of peroxisome proliferator‐activated receptor (PPAR)‐γ was necessary to evoke these effects. These data strongly encourage the systematic study of Octa as a novel candidate promoter of human skin photoprotection.