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A program to test linkage disequilibrium between loci in autotetraploid species
Author(s) -
JULIER BERNADETTE
Publication year - 2009
Publication title -
molecular ecology resources
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.96
H-Index - 136
eISSN - 1755-0998
pISSN - 1755-098X
DOI - 10.1111/j.1755-0998.2009.02530.x
Subject(s) - biology , linkage disequilibrium , microsatellite , genetics , allele , linkage (software) , disequilibrium , evolutionary biology , haplotype , gene , medicine , ophthalmology
No software currently implements a test of linkage disequilibrium in autotetraploid species. We propose a program, LD4X that performs a Fisher's exact test between pairs of alleles at two loci. All combinations of alleles from two loci are treated in turn. If two alleles of a pair of loci have a nonrandom distribution, the markers are considered as linked. The program was tested on a set of microsatellite markers in synthetic alfalfa populations.