Premium
Floor of mouth carcinoma: Surgery still the dominant mode of treatment
Author(s) -
Smee Robert I,
Broadley Kathryn,
Bridger G Patrick,
Williams Janet
Publication year - 2012
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/j.1754-9485.2012.02387.x
Subject(s) - medicine , radiation therapy , proportional hazards model , statistical significance , multivariate analysis , audit , cancer , surgery , log rank test , management , economics
Abstract Introduction: To evaluate the care and outcomes for patients presenting with floor of mouth (FOM) cancers. Methods: In this Ethics‐approved audit, all eligible patients were evaluated with eligibility defined as having a squamous cell carcinoma originating in the FOM. Patient, disease and treatment factors were defined. Primary end points were ultimate local/regional control and cancer‐specific survival. These were analysed according to the Kaplan‐Meier method. The log‐rank test was used to determine statistical significance between survival curves. Multivariate analysis was conducted using Cox regression. Results: A total of 157 patients were eligible for analysis, 76% males and 24% females, with 38 (24%) having a prior diagnosis of cancer. Surgery was performed in 126 patients (54 with pre/postoperative radiotherapy), radiotherapy only in 30 patients and chemotherapy only in 1 patient. Surgery had the best local control (85%), with 23/30 (77%) patients having radiotherapy failing locally. Ultimate regional control was achieved in 89% of patients, while new primaries occurred in 45 (29%) Conclusions: Surgery remains an essential component of the treatment of patients with FOM cancers, with a high likelihood of other cancers developing.