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Low‐osmolar monomeric versus iso‐osmolar dimeric contrast media: An intra‐individual comparison in CT angiography using an animal model
Author(s) -
Behrendt Florian F,
Pietsch Hubertus,
Jost Gregor,
Keil Sebastian,
Mottaghy Felix M,
Günther Rolf W,
Mahnken Andreas H
Publication year - 2011
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/j.1754-9485.2011.02247.x
Subject(s) - iopromide , iodixanol , medicine , hounsfield scale , iodine , aorta , nuclear medicine , iohexol , iopamidol , contrast medium , radiology , computed tomography , cardiology , renal function , materials science , metallurgy
The aim of this study was to compare intra‐individual contrast enhancement in multidetector‐row computed tomography using the low‐osmolar monomeric iopromide 300 and the iso‐osmolar dimeric iodixanol 320. Methods: Repeated computed tomography scanning of the chest of five pigs was performed under standardised conditions using iopromide 300 (300 mg I/mL) and iodixanol 320 (320 mg I/mL) with an identical iodine delivery rate of 1.5 g I/sec and a total iodine dose of 300 mg/kg body weight. Time‐enhancement curves were computed, and pulmonary and aortic peak enhancement, time‐to‐peak and plateau time above 300 Hounsfield units (HU) were analysed. Results: Intra‐individual comparison revealed no statistically significant differences in contrast enhancement between the iopromide 300 and iodixanol 320 in the pulmonary artery and the aorta (620 vs 552 HU; P = 0.13). There was no significant difference between the two CM in the plateau time at the pulmonary artery and the aorta ( P = 0.75 and P = 0.24, respectively). Aortic peak time was significantly earlier with iopromide 300 than with iodixanol 320 ( P = 0.004). Conclusions: Low‐osmolar monomeric and iso‐osmolar dimeric CM provide a similar and suitable vascular contrast enhancement.