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Initial clinical test of a breast‐PET scanner
Author(s) -
Raylman Raymond R,
Abraham Jame,
Hazard Hannah,
Koren Courtney,
Filburn Shan,
Schreiman Judith S,
Kurian Sobha,
Majewski Stan,
Marano Gary D
Publication year - 2011
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/j.1754-9485.2010.02230.x
Subject(s) - medicine , scanner , nuclear medicine , breast cancer , pet ct , positron emission tomography , breast imaging , fluorodeoxyglucose , image quality , radiology , mammography , cancer , artificial intelligence , computer science , image (mathematics)
Summary Introduction: The goal of this initial clinical study was to test a new positron emission/tomography imager and biopsy system (PEM/PET) in a small group of selected subjects to assess its clinical imaging capabilities. Specifically, the main task of this study is to determine whether the new system can successfully be used to produce images of known breast cancer and compare them to those acquired by standard techniques. Methods: The PEM/PET system consists of two pairs of rotating radiation detectors located beneath a patient table. The scanner has a spatial resolution of ∼2 mm in all three dimensions. The subjects consisted of five patients diagnosed with locally advanced breast cancer ranging in age from 40 to 55 years old scheduled for pre‐treatment, conventional whole body PET imaging with F‐18 Fluorodeoxyglucose (FDG). The primary lesions were at least 2 cm in diameter. Results: The images from the PEM/PET system demonstrated that this system is capable of identifying some lesions not visible in standard mammograms. Furthermore, while the relatively large lesions imaged in this study where all visualised by a standard whole body PET/CT scanner, some of the morphology of the tumours (ductal infiltration, for example) was better defined with the PEM/PET system. Significantly, these images were obtained immediately following a standard whole body PET scan. Conclusions: The initial testing of the new PEM/PET system demonstrated that the new system is capable of producing good quality breast‐PET images compared standard methods.