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Tribulations of a prostate cancer trial – Lessons learned from TOAD, a Cancer Council Victoria and Transtasman Radiation Oncology Group trial
Author(s) -
Duchesne Gillian M,
Woo Henry H,
Howell Deborah,
Kaimakamis Mary,
Kemp Evan
Publication year - 2010
Publication title -
journal of medical imaging and radiation oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.31
H-Index - 43
eISSN - 1754-9485
pISSN - 1754-9477
DOI - 10.1111/j.1754-9485.2010.02204.x
Subject(s) - medicine , interim , prostate cancer , clinical trial , interim analysis , family medicine , test (biology) , cancer , oncology , paleontology , archaeology , biology , history
Summary From 2004–2009 a total of 226 out of a target of 750 prostate cancer patients have been randomised into the Timing of Androgen Deprivation trial between immediate and delayed androgen deprivation. A screening log was kept by participating centres for the first 928 patients, which documented the reasons for non‐entry into the trial; 42.7% of screened patients were ineligible and a further 33.0% were not entered for other reasons. Fewer than 10% of patients cited not wanting to be part of a clinical trial as a reason for non‐entry. Strategies to improve recruitment included broadening the eligibility criteria, encouraging international collaboration, the use and support of research nurses in the private health care environment, and the use of phone follow‐up. Recruitment will be completed at the number originally intended to inform the interim analysis designed to test the validity of the statistical assumptions, and a combined survival analysis with the Canadian study is planned.