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Bisphosphonate‐associated osteonecrosis of the jaw,with healing after teriparatide:a review of the literature and a case report
Author(s) -
Narongroeknawin Pongthorn,
Danila Maria I.,
Humphreys Jr Lewis G.,
Barasch Andrei,
Curtis Jeffrey R.
Publication year - 2010
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/j.1754-4505.2009.00128.x
Subject(s) - medicine , teriparatide , osteonecrosis of the jaw , bisphosphonate , osteoporosis , bisphosphonate associated osteonecrosis of the jaw , adjunctive treatment , dentistry , surgery , bone mineral
This paper reports the case history of a patient who had bisphosphonate‐associated osteonecrosis of the jaw (ONJ) in which adjunctive treatment with teriparatide was used. The patient was treated for 5 years with alendronate for osteoporosis and developed ONJ after extraction of maxillary teeth. An implant was placed at the site of the extracted teeth. The pathology report confirmed the clinical diagnosis of ONJ; treatment was changed from alendronate to teriparatide and the ONJ resolved. To our knowledge, this is the third case history reported in the literature in which teriparatide was successfully used as adjunct therapy in ONJ because it has an anabolic effect and presumed role in accelerating bone healing. ONJ is a serious but infrequent condition that has been recently associated with nitrogen‐containing bisphosphonate therapy. Teriparatide may be a useful adjunctive therapy when ONJ develops.