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Treatment of muscle spasticity in patients with cerebral palsy using BTX‐A: a pilot study
Author(s) -
Manzano Felipe Scalco,
Granero Lucia Mercuri,
Masiero Danilo,
Santos Maria Teresa Botti Rodrigues
Publication year - 2004
Publication title -
special care in dentistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.328
H-Index - 41
eISSN - 1754-4505
pISSN - 0275-1879
DOI - 10.1111/j.1754-4505.2004.tb01699.x
Subject(s) - medicine , spasticity , cerebral palsy , spastic , masticatory force , spastic cerebral palsy , botulinum toxin , anesthesia , masseter muscle , physical therapy , dentistry
This study was designed to verify the safety and efficacy of botulinum toxin type A (BTX‐A) used as a neuromuscular block on spastic masticatory musculature of children with cerebral palsy. Six patients who had spastic‐tetraplegic cerebral‐palsy, aged 5 to 20 years were selected. All patients had spasticity of the jaw muscles, bruxism, lower lip trauma, limited mouth opening, and difficulties in cleaning the oral cavity. The patients were sedated under general anesthesia, while the dentist injected the masseter and temporalis muscles bilaterally with 150 and 75 units of BTX‐A each. Clinical examinations were conducted at 7, 14, 30, and 90 days after the initial appointment. We found statistically significant decreases in muscle spasticity and bruxism ( p = 0.002), improved inter‐incisal opening ( p = 0.002), improved oral hygiene ( p = 0.031), and less lower lip trauma ( p = 0.060) after the neuromuscular blocking.