Open AccessRelationship between CA 19‐9 levels and glucose regulation in a middle‐aged and elderly Chinese population
Author(s) -
HUANG Yun,
XU Yu,
BI Yufang,
XU Min,
LU Jieli,
WANG Tiange,
LI Mian,
CHEN Yuhong,
LIU Yu,
HUANG Fei,
XU Baihui,
ZHANG Jie,
WANG Weiqing,
NING Guang
Publication year - 2012
Publication title -
journal of diabetes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.949
H-Index - 43
eISSN - 1753-0407
pISSN - 1753-0393
DOI - 10.1111/j.1753-0407.2011.00179.x
Subject(s) - medicine , diabetes mellitus , endocrinology , blood sugar regulation , hemoglobin , confounding , carbohydrate metabolism , population , odds ratio , plasma glucose , environmental health
Objective: To investigate carbohydrate antigen (CA) 19‐9 levels in subjects with different glucose regulation status and assess the relationship between CA 19‐9 and glucose regulation status in a Chinese population aged 40 years and older. Methods: A total of 2792 participants aged 40 years or older with no history of diabetes were enrolled in the present study from the Songnan region, Shanghai, China. Each participant received a two‐point (at 0 and 2 hours) 75‐g oral glucose tolerance test and measurements of hemoglobin A1c (Hb A1c ) and CA 19‐9 were made. Results: The CA 19‐9 levels increased gradually from normal glucose regulation to impaired glucose regulation to new‐onset diabetic patients (8.81, 9.84, and 11.08 U/mL, respectively, P < 0.0001 for trend). In new‐onset diabetic patients, the CA 19‐9 levels were positively and significantly associated with fasting plasma glucose ( r = 0.20, P < 0.0001), 2 h post‐load plasma glucose ( r = 0.17, P = 0.0007), and Hb A1c ( r = 0.19, P = 0.0001). Meanwhile, patients with new‐onset diabetes had 3.31‐fold (OR, 4.31; 95% CI, 2.00–9.32) increased higher odds ratio of elevated CA 19‐9 as compared with those with normal glucose regulation after adjustments for confounders. Conclusions: The CA 19‐9 levels were significantly higher in diabetic and patients with impaired glucose regulation compared with subjects with normal glucose regulation. Diabetic status was independently associated with elevated CA 19‐9. These results imply that CA 19‐9 might also relate to the endocrine function of the pancreas.