Open AccessMicroRNAs as New Players in the Genomic Galaxy and Disease Puzzles
Author(s) -
Barbarotto Elisa,
Secchiero Paola,
Dasgupta Abhijit,
Fortina Paolo,
Calin George A.,
Hyslop Terry
Publication year - 2008
Publication title -
clinical and translational science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.303
H-Index - 44
eISSN - 1752-8062
pISSN - 1752-8054
DOI - 10.1111/j.1752-8062.2008.00028.x
Subject(s) - microrna , biology , gene , computational biology , disease , gene expression , regulation of gene expression , genetics , bioinformatics , medicine , pathology
MicroRNAs (miRNAs) are a large family of short, single‐stranded, highly conserved noncoding RNAs involved in gene regulation that can regulate gene expression through sequence‐specific base pairing with target messenger RNAs (mRNAs). miRNAs have been implicated in the development of a wide variety of cancers as well as heart disease and other diseases. This review describes the role of miRNAs in human disease, methodology for evaluating miRNA gene expression, and the potential role of miRNAs as therapeutic agents and targets for the treatment of disease.