Open AccessLinkage disequilibrium estimates of contemporary N e using highly variable genetic markers: a largely untapped resource for applied conservation and evolution
Author(s) -
Waples Robin S.,
Do Chi
Publication year - 2010
Publication title -
evolutionary applications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.776
H-Index - 68
ISSN - 1752-4571
DOI - 10.1111/j.1752-4571.2009.00104.x
Subject(s) - linkage disequilibrium , biology , disequilibrium , microsatellite , estimator , population , sample size determination , linkage (software) , evolutionary biology , sample (material) , effective population size , allele frequency , allele , statistics , genetics , genetic variation , mathematics , demography , haplotype , medicine , chemistry , chromatography , sociology , ophthalmology , gene
Genetic methods are routinely used to estimate contemporary effective population size ( N e ) in natural populations, but the vast majority of applications have used only the temporal (two‐sample) method. We use simulated data to evaluate how highly polymorphic molecular markers affect precision and bias in the single‐sample method based on linkage disequilibrium (LD). Results of this study are as follows: (1) Low‐frequency alleles upwardly bias , but a simple rule can reduce bias to