Open AccessParticipation of putative glycoside hydrolases SlgC 1 and SlgC 2 in the biosynthesis of streptolydigin in S treptomyces lydicus
Author(s) -
Gómez Cristina,
Horna Dina H.,
Olano Carlos,
Méndez Carmen,
Salas José A.
Publication year - 2012
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/j.1751-7915.2012.00352.x
Subject(s) - biosynthesis , chemistry , glycoside hydrolase , biochemistry , enzyme
Summary Two genes of the streptolydigin gene cluster in S treptomyces lydicus cluster encode putative family 16 glycoside hydrolases. Both genes are expressed when streptolydigin is produced. Inactivation of these genes affects streptolydigin production when the microorganism is grown in minimal medium containing either glycerol or d ‐glucans as carbon source. Streptolydigin yields in S . lydicus were increased by overexpression of either slgC 1 or slgC 2 .