Open AccessMyxococcus xanthus induces actinorhodin overproduction and aerial mycelium formation by Streptomyces coelicolor
Author(s) -
Pérez Juana,
MuñozDorado José,
Braña Alfredo F.,
Shimkets Lawrence J.,
Sevillano Laura,
Santamaría Ramón I.
Publication year - 2011
Publication title -
microbial biotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.287
H-Index - 74
ISSN - 1751-7915
DOI - 10.1111/j.1751-7915.2010.00208.x
Subject(s) - streptomyces coelicolor , actinorhodin , myxococcus xanthus , mycelium , bacteria , microbiology and biotechnology , biology , streptomyces , hypha , lysis , gene , biochemistry , genetics , botany , mutant
Summary Interaction of the predatory myxobacterium Myxococcus xanthus with the non‐motile, antibiotic producer Streptomyces coelicolor was examined using a variety of experimental approaches. Myxococcus xanthus cells prey on S. coelicolor , forming streams of ordered cells that lyse the S. coelicolor hyphae in the contact area between the two colonies. The interaction increases actinorhodin production by S. coelicolor up to 20‐fold and triggers aerial mycelium production. Other bacteria are also able to induce these processes in S. coelicolor though to a lesser extent. These studies offer new clues about the expression of genes that remain silent or are expressed at low level in axenic cultures and open the possibility of overproducing compounds of biotechnological interest by using potent inducers synthesized by other bacteria.