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Markers of vulnerability to obsessive–compulsive disorder in an ultra‐high risk sample of patients who developed psychosis
Author(s) -
Fontenelle Leonardo F.,
Lin Ashleigh,
Pantelis Christos,
Wood Stephen J.,
Nelson Barnaby,
Yung Alison R.
Publication year - 2012
Publication title -
early intervention in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.087
H-Index - 45
eISSN - 1751-7893
pISSN - 1751-7885
DOI - 10.1111/j.1751-7893.2012.00357.x
Subject(s) - psychosis , anxiety , psychiatry , depression (economics) , psychology , anxiety disorder , clinical psychology , obsessive compulsive , vulnerability (computing) , computer security , computer science , economics , macroeconomics
Aims: The study aims to identify markers of vulnerability to obsessive–compulsive disorder (OCD) in an ultra‐high risk sample of patients who developed psychosis. Methods: Three hundred and eleven patients at ultra‐high risk for psychosis were examined at baseline and after a mean of 7.4 years follow‐up. Patients who developed psychosis with OCD (PSY + OCD; n = 13) and psychosis without OCD (PSY − OCD; n = 45) were compared in terms of socio‐demographic and clinical features. Results: PSY + OCD patients displayed greater severity of depression before and after conversion to PSY + OCD, and increased rates of depressive disorders before exhibiting PSY + OCD. However, they only displayed greater severity of anxiety and increased rates of non‐OCD anxiety disorders after psychosis. Further, PSY + OCD patients were more likely to report a positive family history for anxiety disorders than PSY − OCD. Conclusion: Although depression and a family history of anxiety disorder may act as vulnerability markers for OCD in psychosis, the resulting anxiety may be a correlate or a consequence of PSY + OCD.