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Early detection and intervention evaluation for people at high‐risk of psychosis‐2 (EDIE‐2): trial rationale, design and baseline characteristics
Author(s) -
Morrison Anthony P.,
Stewart Suzanne L.K.,
French Paul,
Bentall Richard P.,
Birchwood Max,
Byrne Rory,
Davies Linda M.,
Fowler David,
Gumley Andrew I.,
Jones Peter B.,
Lewis Shôn W.,
Murray Graham K.,
Patterson Paul,
Dunn Graham
Publication year - 2011
Publication title -
early intervention in psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.087
H-Index - 45
eISSN - 1751-7893
pISSN - 1751-7885
DOI - 10.1111/j.1751-7893.2010.00254.x
Subject(s) - baseline (sea) , intervention (counseling) , psychosis , psychiatry , medicine , psychology , political science , law
Aims: Much research has begun to focus on the identification of people who are at high risk of developing psychosis, and clinical services have been initiated for this population. However, only a small number of studies have reported on the efficacy of interventions for preventing or delaying the onset of psychosis. The results of prior work suggest that cognitive therapy (CT) may be an effective, well‐tolerated treatment. We report on the rationale and design for a large‐scale, multi‐site randomized, controlled trial of CT for people who are assessed to be at high risk of psychosis because of either state or state‐plus‐trait risk factors. Methods: The study employs a single‐blind design in which all participants receive frequent mental‐state monitoring, which will efficiently detect transition to psychosis, and half are randomized to weekly sessions of CT for up to 6 months. Participants will be followed‐up for a minimum of 12 months and to a maximum of 2 years. Results: We report the characteristics of the final sample at baseline ( n = 288). Conclusions: Our study aimed to expand the currently limited evidence base for best practice in interventions for individuals at high risk of psychosis.