Open AccessPrognostic Impact of Baseline Low Blood Pressure in Hypertensive Patients With Stable Coronary Artery Disease of Daily Clinical Practice
Author(s) -
Ortiz Martín Ruiz,
Romo Elías,
Mesa Dolores,
Delgado Mónica,
Ogayar Cristina,
Anguita Manuel,
Castillo Juan C.,
Arizón José M.,
de Lezo José Suárez
Publication year - 2012
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1751-7176.2012.00638.x
Subject(s) - medicine , coronary artery disease , cardiology , blood pressure , baseline (sea) , clinical practice , disease , physical therapy , oceanography , geology
J Clin Hypertens (Greenwich). 2012;00:00–00 ©2012 Wiley Periodicals, Inc. The authors’ aim was to investigate the prognostic value of first‐visit systolic and diastolic blood pressure (SBP/DBP) in hypertensive patients with stable coronary artery disease (sCAD) in conditions of contemporary daily clinical practice. From February 1, 2000, to January 31, 2004, 690 consecutive hypertensive patients with sCAD (mean age 68±10 years, 65% male) were prospectively followed in the outpatient cardiology clinic for major events (acute coronary syndrome, revascularization, stroke, heart failure, or death) and associations with baseline SBP/DBP were investigated. At first visit, median SBP/SDP were 130/75 mm Hg (interquartile range, 25–75; 120–140/70–80 mm Hg). After 25 months of follow‐up (median), 19 patients died (2.8%); 10 from cardiovascular causes (1.5%), 87 patients experienced a coronary event (13%), and 130 patients (19%) a major event. After adjusting for baseline variables, DBP <75 mm Hg or SBP <130 mm Hg resulted in independent predictors of major events (hazard ratio [HR], 1.52; 95% confidence interval [CI], 1.07–2.16, P =.02; HR, 1.68; 95% CI, 1.18–2.40, P =.004, respectively), coronary events (HR, 1.78; 95% CI, 1.15–2.75, P =.009; HR, 1.84; 95% CI, 1.20–2.83, P =.005, respectively), and cardiovascular mortality (HR, 7.02; 95% CI, 1.26–39.04, P =.03; HR, 9.26; 95% CI, 1.33–64.32, P =.02, respectively). In this study, a low first‐visit SBP or DBP was associated with an adverse prognosis in hypertensive patients with sCAD of contemporary daily clinical practice.