Open AccessEffect of the rs168924 Single‐Nucleotide Polymorphism in the SLC6A2 Catecholamine Transporter Gene on Blood Pressure in Caucasians
Author(s) -
Zolk Oliver,
Ott Christian,
Fromm Martin F.,
Schmieder Roland E.
Publication year - 2012
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1751-7176.2012.00618.x
Subject(s) - medicine , blood pressure , single nucleotide polymorphism , norepinephrine transporter , ambulatory blood pressure , endocrinology , diastole , snp , population , genotype , genotyping , polymorphism (computer science) , allele , cardiology , cohort , norepinephrine , gene , genetics , biology , environmental health , dopamine
J Clin Hypertens (Greenwich) . 2012; 14:293–298. ©2012 Wiley Periodicals, Inc. The NG_016969.1 :g.5003A>G promoter polymorphism (rs168924) in the SLC6A2 norepinephrine transporter gene was found to be predictive of the hypertensive status in a Japanese population, but no data are available for Caucasians. Genotyping for rs168924 was performed in 282 young men with normal blood pressure (BP), grade 1 or 2 hypertension. In addition to casual BP, 24‐hour ABPM and echocardiography were performed. Multiple regression analysis revealed a significant association of rs168924 genotype with diagnosis of hypertension ( P =.044), casual systolic BP (SBP) levels ( P =.028), and daytime ambulatory SBP ( P =.02). The finding that rs168924 was also significantly associated with diastolic posterior wall thickness ( P =.041), an echocardiographic index of hypertensive cardiac target organ damage, further supports the notion that the rs168924 SNP in SLC6A2 in fact might influence BP. Unlike previous findings in a Japanese population, in our Caucasian study cohort the presence of the minor rs168924 G allele was associated with lower prevalence of hypertension. J Clin Hypertens (Greenwich) . 2012;00:00–00. ©2012 Wiley Periodicals, Inc.