Open AccessPrediction of Primary vs Secondary Hypertension in Children
Author(s) -
Baracco Rossana,
Kapur Gaurav,
Mattoo Tej,
Jain Amrish,
Valentini Rudolph,
Ahmed Maheen,
Thomas Ronald
Publication year - 2012
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/j.1751-7176.2012.00603.x
Subject(s) - medicine , secondary hypertension , renal function , logistic regression , essential hypertension , blood pressure , retrospective cohort study , pediatrics , creatinine , cardiology
J Clin Hypertens (Greenwich) . 2012; 14:316–321. ©2012 Wiley Periodicals, Inc. Despite current guidelines, variability exists in the workup of hypertensive children due to physician preferences. The study evaluates primary vs secondary hypertension diagnosis from investigations routinely performed in hypertensive children. This retrospective study included children 5 to 19 years with primary and secondary hypertension. The proportions of abnormal laboratory and imaging tests were compared between primary and secondary hypertension groups. Risk factors for primary vs secondary hypertension were evaluated by logistic regression and likelihood function analysis. Patients with secondary hypertension were younger (5–12 years) and had a higher proportion of abnormal creatinine, renal ultrasound, and echocardiogram findings. There was no significant difference in abnormal results of thyroid function, urine catecholamines, plasma renin, and aldosterone. Abnormal renal ultrasound findings and age were predictors of secondary hypertension by regression and likelihood function analysis. Children aged 5 to 12 years with abnormal renal ultrasound findings and high diastolic blood pressures are at higher risk for secondary hypertension that requires detailed evaluation.